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1

Immobilization of Natural Products on Glass Slides by Using a Photoaffinity Reaction and the Detection of Protein–Small-Molecule Interactions

Naoki Kanoh, Saori Kumashiro, Siro Simizu, Yasumitsu Kondoh, Satoru Hatakeyama, Hideo Tashiro, Hiroyuki Osada

Journal:

Angewandte Chemie International Edition

Year:

2003

Language:

english

File:

PDF, 209 KB

english, 2003

2

Immobilization of Natural Products on Glass Slides by Using a Photoaffinity Reaction and the Detection of Protein–Small-Molecule Interactions

Naoki Kanoh, Saori Kumashiro, Siro Simizu, Yasumitsu Kondoh, Satoru Hatakeyama, Hideo Tashiro, Hiroyuki Osada

Journal:

Angewandte Chemie

Year:

2003

Language:

english

File:

PDF, 208 KB

english, 2003

3

Photo-Cross-Linked Small-Molecule Affinity Matrix for Facilitating Forward and Reverse Chemical Genetics

Naoki Kanoh, Kaori Honda, Siro Simizu, Makoto Muroi, Hiroyuki Osada

Journal:

Angewandte Chemie

Year:

2005

Language:

english

File:

PDF, 459 KB

english, 2005

4

Photo-Cross-Linked Small-Molecule Affinity Matrix for Facilitating Forward and Reverse Chemical Genetics

Naoki Kanoh, Kaori Honda, Siro Simizu, Makoto Muroi, Hiroyuki Osada

Journal:

Angewandte Chemie

Year:

2005

File:

PDF, 173 KB

2005

5

Photo-Cross-Linked Small-Molecule Affinity Matrix for Facilitating Forward and Reverse Chemical Genetics

Naoki Kanoh, Kaori Honda, Siro Simizu, Makoto Muroi, Hiroyuki Osada

Journal:

Angewandte Chemie International Edition

Year:

2005

Language:

english

File:

PDF, 459 KB

english, 2005

6

Photo-Cross-Linked Small-Molecule Affinity Matrix for Facilitating Forward and Reverse Chemical Genetics

Naoki Kanoh, Kaori Honda, Siro Simizu, Makoto Muroi, Hiroyuki Osada

Journal:

Angewandte Chemie International Edition

Year:

2005

File:

PDF, 173 KB

2005

7

On-Chip Fragment-Based Approach for Discovery of High-Affinity Bivalent Inhibitors

Isao Miyazaki, Siro Simizu, Keisuke Ishida, Hiroyuki Osada

Journal:

Year:

2009

Language:

english

File:

PDF, 716 KB

english, 2009

8

Structure–Affinity Relationship Study of Bleomycins and Shble Protein by Use of a Chemical Array

Isao Miyazaki, Hideo Okumura, Siro Simizu, Yoshikazu Takahashi, Naoki Kanoh , Yasuhiko Muraoka, Yoshiaki Nonomura, Hiroyuki Osada

Journal:

Year:

2009

Language:

english

File:

PDF, 547 KB

english, 2009

9

Development of a Vaccinia H1-Related (VHR) Phosphatase Inhibitor with a Nonacidic Phosphate-Mimicking Core Structure

Dr. Go Hirai, Dr. Ayako Tsuchiya, Yusuke Koyama, Dr. Yuko Otani, Kana Oonuma, Dr. Kosuke Dodo, Dr. Siro Simizu, Dr. Hiroyuki Osada, Dr. Mikiko Sodeoka

Journal:

Year:

2011

Language:

english

File:

PDF, 682 KB

english, 2011

10

Rational design and synthesis of novel heparan sulfate mimetic compounds as antiadhesive agents

Keisuke Ishida, Siro Simizu, Takayuki Teruya, Michal K. Wierzba, Hiroyuki Osada

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 434 KB

english, 2004

11

Novel Heparan Sulfate Mimetic Compounds as Antitumor Agents

Keisuke Ishida, Michal K Wierzba, Takayuki Teruya, Siro Simizu, Hiroyuki Osada

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 775 KB

english, 2004

12

Bcl-2 Inhibits Calcineurin-mediated Fas Ligand Expression in Antitumor Drug-treated Baby Hamster Kidney Cells

Siro Simizu, Futoshi Shibasaki, Hiroyuki Osada

Journal:

Year:

2000

Language:

english

File:

PDF, 146 KB

english, 2000

13

Heparanase as a molecular target of cancer chemotherapy

Siro Simizu, Keisuke Ishida, Hiroyuki Osada

Journal:

Year:

2004

Language:

english

File:

PDF, 404 KB

english, 2004

14

Dephosphorylation of Bcl-2 by protein phosphatase 2A results in apoptosis resistance

Siro Simizu, Yuki Tamura, Hiroyuki Osada

Journal:

Year:

2004

Language:

english

File:

PDF, 386 KB

english, 2004

15

10.1038/35041102

Osada, Hiroyuki, Simizu, Siro

Journal:

Nature Cell Biology

Year:

2000

Language:

english

File:

PDF, 162 KB

english, 2000

16

A cell-based screening to detect inhibitors of BRAF signaling pathway

Asami, Yukihiro, Mori, Mihoko, Koshino, Hiroyuki, Sekiyama, Yasuyo, Teruya, Takayuki, Simizu, Siro, Usui, Takeo, Osada, Hiroyuki

Journal:

The Journal of Antibiotics

Year:

2009

Language:

english

File:

PDF, 147 KB

english, 2009

17

A small-molecule inhibitor shows that pirin regulates migration of melanoma cells

Miyazaki, Isao, Simizu, Siro, Okumura, Hideo, Takagi, Satoshi, Osada, Hiroyuki

Journal:

Nature Chemical Biology

Year:

2010

Language:

english

File:

PDF, 802 KB

english, 2010

18

Requirement of the conserved, hydrophobic C-terminus region for the activation of heparanase

Ngit Shin Lai, Siro Simizu, Daiki Morisaki, Makoto Muroi, Hiroyuki Osada

Journal:

Experimental Cell Research

Year:

2008

Language:

english

File:

PDF, 1.33 MB

english, 2008

19

Protein disulfide isomerase-mediated disulfide bonds regulate the gelatinolytic activity and secretion of matrix metalloproteinase-9

Maola M.G. Khan, Siro Simizu, Takehiro Suzuki, Akiko Masuda, Makoto Kawatani, Makoto Muroi, Naoshi Dohmae, Hiroyuki Osada

Journal:

Experimental Cell Research

Year:

2012

Language:

english

File:

PDF, 1.22 MB

english, 2012

20

Involvement of Protein Kinase C-Regulated Ceramide Generation in Inostamycin-Induced Apoptosis

Makoto Kawatani, Siro Simizu, Hiroyuki Osada, Minoru Takada, Nadir Arber, Masaya Imoto

Journal:

Experimental Cell Research

Year:

2000

Language:

english

File:

PDF, 300 KB

english, 2000

21

Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells

Siro Simizu, Takayuki Teruya, Toshihiko Nogawa, Harumi Aono, Masashi Ueki, Masakazu Uramoto, Yuichi Kobayashi, Hiroyuki Osada

Journal:

Biochemical and Biophysical Research Communications

Year:

2009

Language:

english

File:

PDF, 572 KB

english, 2009

22

A Case of Fulminant Eosinophilic Myocarditis Treated Effectively with Methylprednisolone Pulse Therapy

Hiroshi Mikamo, Tsutomu Hirohashi, Hajime Kiyokawa, Takahiro Nakagami, Keiichi Hirano, Masayo Suzuki, Kazuhiro Simizu, Takuo Iizuka, Hiroyuki Hiruta, Hirohumi Noike

Journal:

Journal of Cardiac Failure

Year:

2011

Language:

english

File:

PDF, 38 KB

english, 2011

23

The phosphorylation status and anti-apoptotic activity of Bcl-2 are regulated by ERK and protein phosphatase 2A on the mitochondria

Yuki Tamura, Siro Simizu, Hiroyuki Osada

Journal:

Year:

2004

Language:

english

File:

PDF, 331 KB

english, 2004

24

Phoslactomycin targets cysteine-269 of the protein phosphatase 2A catalytic subunit in cells

Takayuki Teruya, Siro Simizu, Naoki Kanoh, Hiroyuki Osada

Journal:

Year:

2005

Language:

english

File:

PDF, 353 KB

english, 2005

25

Antigenic characterization of a formalin-inactivated poliovirus vaccine derived from live-attenuated Sabin strains

Yoshio Tano, Hiroyuki Shimizu, Javier Martin, Yorihiro Nishimura, Bunsiti Simizu, Tatsuo Miyamura

Journal:

Year:

2007

Language:

english

File:

PDF, 236 KB

english, 2007

26

Transmembrane domain of Bcl-2 is required for inhibition of ceramide synthesis, but not cytochrome c release in the pathway of inostamycin-induced apoptosis

Makoto Kawatani, Madoka Uchi, Siro Simizu, Hiroyuki Osada, Masaya Imoto

Journal:

Experimental Cell Research

Year:

2003

Language:

english

File:

PDF, 485 KB

english, 2003

27

Expression of heparanase in human tumor cell lines and human head and neck tumors

Siro Simizu, Keisuke Ishida, Michal K. Wierzba, Taka-Aki Sato, Hiroyuki Osada

Journal:

Year:

2003

Language:

english

File:

PDF, 203 KB

english, 2003

28

Multiwalled Carbon Nanotubes Specifically Inhibit Osteoclast Differentiation and Function

Narita, Nobuyo, Kobayashi, Yasuhiro, Nakamura, Hiroaki, Maeda, Kazuhiro, Ishihara, Akihiro, Mizoguchi, Toshihide, Usui, Yuki, Aoki, Kaoru, Simizu, Masayuki, Kato, Hiroyuki, Ozawa, Hidehiro, Udagawa, N

Journal:

Year:

2009

Language:

english

File:

PDF, 2.12 MB

english, 2009

29

Synthesis of (+)-Vinblastine and Its Analogues †

Miyazaki, Tohru, Yokoshima, Satoshi, Simizu, Siro, Osada, Hiroyuki, Tokuyama, Hidetoshi, Fukuyama, Tohru

Journal:

Organic Letters

Year:

2007

Language:

english

File:

PDF, 160 KB

english, 2007

30

Discovery of a Small Molecule PDI Inhibitor That Inhibits Reduction of HIV-1 Envelope Glycoprotein gp120

Khan, Maola M. G., Simizu, Siro, Lai, Ngit Shin, Kawatani, Makoto, Shimizu, Takeshi, Osada, Hiroyuki

Journal:

ACS Chemical Biology

Year:

2011

Language:

english

File:

PDF, 2.53 MB

english, 2011

31

Cleavable Linker for Photo-Cross-Linked Small-Molecule Affinity Matrix

Kanoh, Naoki, Takayama, Hiroshi, Honda, Kaori, Moriya, Takashi, Teruya, Takayuki, Simizu, Siro, Osada, Hiroyuki, Iwabuchi, Yoshiharu

Journal:

Bioconjugate Chemistry

Year:

2010

Language:

english

File:

PDF, 2.19 MB

english, 2010

32

Robust and Systematic Drug Screening Method Using Chemical Arrays and the Protein Library: Identification of Novel Inhibitors of Carbonic Anhydrase II

MIYAZAKI, Isao, SIMIZU, Siro, ICHIMIYA, Harumi, KAWATANI, Makoto, OSADA, Hiroyuki

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2008

Language:

english

File:

PDF, 250 KB

english, 2008

33

Polymorphism and Crystal Growth of Organic Conductor (BEDT-TTF) 2 I 3

Yoshimoto, Noriyuki, Takayuki, Simizu, Gamachi, Hiroyuki, Yoshizawa, Masahito

Journal:

Molecular Crystals and Liquid Crystals Science and Technology Section A Molecular Crystals and Liquid Crystals

Year:

1999

Language:

english

File:

PDF, 261 KB

english, 1999

34

Secretion of Heparanase Protein Is Regulated by Glycosylation in Human Tumor Cell Lines

Simizu, Siro, Ishida, Keisuke, Wierzba, Michal K., Osada, Hiroyuki

Journal:

Journal of Biological Chemistry

Year:

2004

Language:

english

File:

PDF, 919 KB

english, 2004

35

Identification of a novel compound that inhibits osteoclastogenesis by suppressing nucleoside transporters

Katsuyama, Shun, Sugino, Kumi, Sasazawa, Yukiko, Nakano, Yoshihiko, Aono, Harumi, Morishita, Keisuke, Kawatani, Makoto, Umezawa, Kazuo, Osada, Hiroyuki, Simizu, Siro

Journal:

Year:

2016

Language:

english

File:

PDF, 507 KB

english, 2016

36

Visualizing the Dynamics of Cerebral Aneurysms with Four-dimensional Computed Tomographic Angiography

Ishida, Fujimaro, Ogawa, Hiroyuki, Simizu, Takeo, Kojima, Tadashi, Taki, Waro

Journal:

Year:

2005

Language:

english

File:

PDF, 3.37 MB

english, 2005

37

Exploitation of Heparanase Inhibitors from Microbial Metabolites Using an Efficient Visual Screening System

ISHIDA, KEISUKE, TERUYA, TAKAYUKI, SIMIZU, SIRO, OSADA, HIROYUKI

Journal:

The Journal of Antibiotics

Year:

2004

Language:

english

File:

PDF, 2.07 MB

english, 2004

38

A Measurement of 5-Androstene-3^|^beta;, 17^|^beta;-Diol in Human Serum

HIRATO, Kumiko, SUZUKI, Tomoko, SIMIZU, Atsusi, HIDAKA, Teruyuki, YANAIHARA, Takumi, NAKAYAMA, Tetsuya, OSHIMA, Hiroyuki, KANBEGAWA, Akira

Journal:

Folia Endocrinologica Japonica

Year:

1982

File:

PDF, 588 KB

1982

39

10.1299/kikaib.49.493

FARAG, S.M., ARAI, Masataka, SIMIZU, Masanori, HIROYASU, Hiroyuki

Journal:

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series B

Year:

1983

File:

PDF, 832 KB

1983

40

Epidemiology of the Diseases of Blood and Hematopoietic System

AOKI, Kunio, OHNO, Yoshiyuki, SIMIZU, Hiroyuki, KUROISHI, Tetsuo, OHTANI, Motohiko

Journal:

Japanese Journal of Medicine

Year:

1977

Language:

english

File:

PDF, 1.90 MB

english, 1977

41

The Potential of Protein Disulfide Isomerase as a Therapeutic Drug Target

Khan, Maola M. G., Simizu, Siro, Kawatani, Makoto, Osada, Hiroyuki

Journal:

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics

Year:

2011

Language:

english

File:

PDF, 478 KB

english, 2011

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